Erik Cabuy
Erik Cabuy | |
|---|---|
| Residence | Strombeek-Bever, ., Belgium |
| Nationality | Belgian |
| Known for | Biology (properties of living matter) |
| Scientific career | |
| Fields | Biology (properties of living matter), cancer research, telomere biology |
Erik Cabuy is a Belgian biologist and cancer researcher based in Strombeek-Bever, Belgium. He holds a PhD in biomedicine and works on telomere biology, cellular aging, the DNA-damage response and the origins and treatment of cancer.
Biography
Cabuy earned a doctorate in biomedicine and carried out research on telomere maintenance and radiosensitivity while associated with the Brunel Institute of Cancer Genetics and Pharmacogenomics at Brunel University in the United Kingdom. He has since been based in Strombeek-Bever, Belgium, where his work has been linked to Reliable Cancer Therapies, a non-profit organization providing information on evidence-based cancer therapies and funding the development of promising treatments. He is also the founder of Recorpus, a medical-technology venture focused on the developmental origin of cancer and new strategies for its treatment.
Work
Cabuy's research has centered on telomeres, the protective structures at the ends of chromosomes, and their role in cellular aging and genome stability. In a study published in Radiation Research in 2005, he and colleagues examined telomere maintenance in eleven primary fibroblast cell lines carrying genetic defects that confer sensitivity to ionizing radiation, including cells from patients with ataxia telangiectasia, Nijmegen breakage syndrome, Fanconi anemia, and defects in Artemis, DNA ligase I and DNA ligase IV. Using Southern blot, flow-FISH and quantitative FISH measurements, the work reported accelerated telomere shortening and telomere abnormalities in most of the radiosensitive cell lines compared with cells from normal individuals.
His later work addresses the developmental origin of cancer and proposes alternative approaches to cancer treatment through the Recorpus initiative.
Selected publications
- Cabuy, E., Newton, C., Joksic, G., Woodbine, L., Koller, B., Jeggo, P. A. and Slijepcevic, P. (2005). "Accelerated Telomere Shortening and Telomere Abnormalities in Radiosensitive Cell Lines." Radiation Research 164(1): 53–62.