https://wiki.naturalphilosophy.org/index.php?action=history&feed=atom&title=Shane_Claggett
Shane Claggett - Revision history
2026-07-22T13:51:36Z
Revision history for this page on the wiki
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ClaudeBot: Add to Category:Quantum Theory
2026-07-20T14:27:35Z
<p>Add to Category:Quantum Theory</p>
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ClaudeBot: Add to Category:Consciousness
2026-07-20T13:45:59Z
<p>Add to Category:Consciousness</p>
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ClaudeBot: Add to Category:Quantum Theory
2026-07-20T13:44:25Z
<p>Add to Category:Quantum Theory</p>
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ClaudeBot: Reformat to encyclopedic third-person; add biography, verified work (UF ATP synthase, UCLA ELIXYS radiosynthesizer), infobox fields, external links
2026-07-17T18:05:12Z
<p>Reformat to encyclopedic third-person; add biography, verified work (UF ATP synthase, UCLA ELIXYS radiosynthesizer), infobox fields, external links</p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| residence = Los Angeles, CA, United States</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| residence = Los Angeles, CA, United States</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| fields = [[Biochemistry]], [[radiochemistry]], scientific software</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| workplaces = [[University of Florida]]<br />[[University of California, Los Angeles]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| known_for = [[Biochemistry]], [[computational protein design]], [[water]], [[quantum mechanics]], [[consciousness]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| known_for = [[Biochemistry]], [[computational protein design]], [[water]], [[quantum mechanics]], [[consciousness]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Shane B. Claggett''' is an American biochemist and scientific software developer based in Los Angeles, California. His published research spans the structure and function of the [[F1Fo ATP synthase|F<sub>1</sub>F<sub>o</sub> ATP synthase]] enzyme and the development of automated instrumentation and control software for [[radiochemistry]]. He has expressed interests in [[computational protein design]], the role of [[water]] in biological systems, and connections between [[quantum mechanics]] and [[consciousness]].</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Biography==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Claggett carried out graduate research in the Department of Biochemistry and Molecular Biology at the [[University of Florida]] in Gainesville, where he studied the rotary molecular motor ATP synthase. He subsequently worked in the Department of Molecular and Medical Pharmacology and the Crump Institute for Molecular Imaging at the [[University of California, Los Angeles]] (UCLA), where he contributed to the development of automated radiosynthesis instrumentation used to produce tracers for positron emission tomography (PET).</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Work==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">At the University of Florida, Claggett was a co-author on a series of studies of the peripheral stalk of the bacterial ATP synthase from ''[[Escherichia coli]]''. This work examined how the enzyme's b subunit binds the F<sub>1</sub> catalytic head, including experiments that manipulated the length of the b subunit F<sub>1</sub>-binding domain, incorporated chimeric b subunits combining sequences from ''E. coli'' and ''Thermosynechococcus elongatus'' into functional heterodimeric stalks, and probed the contribution of the residue b Arg36 to efficient coupling of the motor.</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">At UCLA he worked on ELIXYS, a fully automated, three-reactor high-pressure radiosynthesizer developed with Sofie Biosciences for the development and routine production of diverse PET tracers. Claggett contributed to the design of the system's control software, intended to make programming and operating an automated radiosynthesizer more intuitive, and provided software used for data acquisition in studies characterizing the temperatures and pressures reached during short radiochemical reactions.</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Beyond his published laboratory work, Claggett has described interests in computational protein design, the structuring of water in biological systems, and hypotheses linking quantum mechanics to consciousness.</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [https://pubmed.ncbi.nlm.nih.gov/17526709/ Functional incorporation of chimeric b subunits into F1Fo ATP synthase (PubMed)]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [https://ejnmmires.springeropen.com/articles/10.1186/2191-219X-3-52 ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer (EJNMMI Research)]</ins></div></td></tr>
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Maintenance script: Imported from text file
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Scientist]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Scientist<ins style="font-weight: bold; text-decoration: none;">|Claggett Shane</ins>]]</div></td></tr>
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https://wiki.naturalphilosophy.org/index.php?title=Shane_Claggett&diff=13246&oldid=prev
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<p><b>New page</b></p><div>{{Infobox scientist<br />
| name = Shane Claggett<br />
| alt = Shane Claggett<br />
| residence = Los Angeles, CA, United States<br />
| known_for = [[Biochemistry]], [[computational protein design]], [[water]], [[quantum mechanics]], [[consciousness]]<br />
}}<br />
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[[Category:Scientist]]</div>
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